ip.htm ... ... .... ip.htm activities,(61-67) and the action and synthesis of prostaglandins and lipoperoxides.(48,68-71). In short, radical species can attack most biological substrates from large macromolecules to smaller molecules such as catechols melanins (72-75)and the stable radical derivatives produced in spin-trapping measurements.(7,28)

TABLE I. Historical perspective of biological free radicals (a few representative events)

1800's -- Vitreous chalchosis(22O) association between deafness and pigmentary abnormalities(243)

1920's -- Radical mechanisms responsible for radiation and oxygen toxicity

1950 -- Protein antiinflammatory contaminant of hyaluronidase (Wydase) recognized by Schulte(l84)

1952 -- Application of ES R to biological materials(261)

1958-64 -- Free radical metabolites of the phenothiazines,(77,80) the melanins(73-75), Hormones(88), carbon tetrachloride(82), "Quantum Biochemistry"(134)

loss nitrone cerovive is the tradmark of the astrazeneca corporation renovis